Review: NAD+ Supplement for Dogs - Benefits and Considerations

As our canine companions age, we naturally seek ways to support their health and vitality. Nicotinamide adenine dinucleotide, or NAD+, is a critical coenzyme involved in numerous cellular processes. Interest in NAD+ supplements for dogs is growing, prompting a closer look at their potential benefits and safety. This review will explore the science behind NAD+ and its role in canine health, providing information to help you make informed decisions about supplementation.

NAD+ is essential for cellular energy production, DNA repair, and maintaining healthy metabolism. Declining NAD+ levels are associated with aging and age-related conditions. Supplementing with NAD+ precursors, like nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN), aims to boost NAD+ levels and support overall health. Learn more about NAD+

Understanding NAD+ and Its Role in Canine Health

NAD+ is a vital coenzyme found in every cell of a dog's body. It plays a crucial role in several key biological processes, including:

• Energy Production: NAD+ is essential for converting nutrients into cellular energy (ATP) through the citric acid cycle and oxidative phosphorylation.
• DNA Repair: NAD+ activates enzymes called sirtuins, which are involved in DNA repair and genome stability.
• Cell Signaling: NAD+ participates in cell signaling pathways that regulate inflammation, stress response, and cell survival.
• Metabolism: NAD+ is important for metabolic processes, helping to maintain healthy weight and insulin sensitivity.

NAD+ falls with age in multiple tissues studied in rodents, and in blood in humans. No canine aging study has been published, so the same cannot be said from direct dog data. This decline affects cellular energy and overall vitality. Supplementing with NAD+ precursors aims to counteract this decline and support optimal cellular function.

LongTails' NAD+ Precursor supplement supports cellular health and vitality.

Potential Benefits of NAD+ Supplements for Dogs

While research on NAD+ supplementation in dogs is still emerging, preliminary studies and extrapolation from human and rodent research suggest several potential benefits:

• Supports Cellular Systems: By boosting NAD+ levels, supplements may help mitigate age-related decline in cellular function and overall vitality. This can manifest as increased energy levels and improved cognitive function.
• Supports Cellular Energy: No published canine study shows an NAD+ precursor improving cognition, and the human trials that measured it were null, so the supported mechanism is cellular energy and DNA repair rather than a brain benefit. This may help maintain cognitive function and memory in aging dogs.
• Helps Maintain Metabolic Health: NAD+ is involved in regulating glucose metabolism and insulin sensitivity. Supplementation may help maintain healthy blood sugar levels and support a healthy weight.
• Supports Cardiovascular Health: NAD+ promotes healthy blood vessel function and helps maintain normal blood pressure. This may contribute to overall cardiovascular health in dogs.
• Supports Muscle Function: NAD+ plays a role in muscle energy production and repair. We do not make muscle claims for this ingredient; the supported mechanism is cellular energy.

Considerations When Choosing an NAD+ Supplement for Your Dog

If you're considering an NAD+ supplement for your dog, it's essential to choose a high-quality product and consult with your veterinarian. Here are some factors to consider:

• Form of NAD+ Precursor: The most common NAD+ precursors in supplements are nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). Both have shown promise in raising NAD+ levels, but NR has more established safety data in animals.
• Quality and Purity: Choose a supplement from a reputable manufacturer that uses high-quality ingredients and undergoes third-party testing for purity and potency. Look for third-party testing for potency and purity, manufacturing in a cGMP facility, and a printed per-ingredient milligram dose rather than a proprietary blend.
• Dosage: The appropriate dosage of NAD+ precursor for dogs varies depending on their size, age, and health condition. Consult with your veterinarian to determine the optimal dosage for your dog.
• Safety: While NAD+ precursors are generally considered safe, some dogs may experience mild side effects like nausea or digestive upset. Start with a low dose and gradually increase it as tolerated.
• Interactions: Inform your veterinarian about all medications and supplements your dog is taking, as NAD+ precursors may interact with certain drugs.

Conclusion

NAD+ supplements hold promise for supporting healthy aging and overall vitality in dogs. By boosting NAD+ levels, these supplements may promote cellular energy, DNA repair, and metabolic health. However, it's crucial to choose a high-quality product, consult with your veterinarian, and monitor your dog for any potential side effects. Further research is needed to fully understand the long-term benefits and safety of NAD+ supplementation in dogs. As always, consult with your veterinarian before starting any new supplement regimen for your pet.

References

[1] Yoshino, J., Baur, J. A., & Imai, S. I. (2018). NAD+ biosynthesis, utilization, and manipulation: therapeutic potential of NAD+-raising interventions. Cell metabolism, 27(3), 513-528.

[2] Rajman, L., Chwalek, K., & Sinclair, D. A. (2018). Therapeutic potential of nicotinamide mononucleotide (NMN): the current evidence. Nutrients, 10(12), 1795.

[3] Dellinger, R. W., Santos, V. S., Conrad, G. T., Abrantes, J. L., Wolfson, A. J., Mattison, J. A., ... & Mitchell, S. J. (2017). Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels and improves muscle function in old mice. Aging (Albany NY), 9(6), 1386.